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If I'm coming from academia where I worked at a hospital where I billed insurances for the last 20 years, and now I'm working at the FDA where everything we do is giant pharmaceutical companies that love the existing ecosystem because it builds a moat around their ability to monetize drugs and chronic disease, there's a benefit there to play within that ecosystem

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If the same 10 mg vial is reconstituted with 2.5 mL the concentration doubles to 4 mg/mL and the mL values halve: 250 g becomes 0.0625 mL, which is hard to draw accurately on a U-100 syringe